Transcription as a source of genome instability
نویسندگان
چکیده
منابع مشابه
L1 Elements as a Source of Environmentally Sensitive Genetic Instability
LINE-1 is the only active autonomous non-LTR human retroelement. The expression and activity of these elements contribute to human genomic instability. LINE-1 elements comprise 17% of the human genome, which translates into about 5x10 L1 copies, the majority of which are defective due to truncations at their 5’ end. We have analyzed the expression profiles of endogenous L1 elements from differe...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2012
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3152